Safety Information
Important safety information for Mounjaro (tirzepatide)
For complete safety details and instructions, refer to the patient information leaflet included with your Mounjaro.
Common Side Effects
Most side effects are gastrointestinal and often improve as your dose is increased gradually. For many people, they are manageable and often lessen over time.
Nausea
Usually improves over time
Diarrhea
Often mild and temporary
Decreased appetite
A common, expected effect
Vomiting
More common during dose increases
Constipation
Can be managed with fiber and hydration
Abdominal discomfort
Usually mild
Injection site reactions
Usually minor and temporary
Managing Side Effects
For Nausea
- Eat smaller, more frequent meals
- Avoid fatty, greasy, or spicy foods
- Eat slowly and stop when you feel full
- Stay upright after eating
- Try bland foods (like toast or crackers)
For Constipation
- Increase fiber gradually
- Drink plenty of water
- Exercise regularly
- Consider a fiber supplement
- Ask your provider if a stool softener is appropriate
General Tips
- Stay well hydrated throughout the day
- Follow your titration schedule
- Take Mounjaro at a consistent time
- Keep a symptom diary
- Report persistent or worsening symptoms
Who Should Not Take Mounjaro
Review your medical history with your healthcare provider before starting treatment.
Personal or family history of medullary thyroid carcinoma (MTC)
Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Known hypersensitivity to tirzepatide
Pregnancy or breastfeeding
Drug Interactions
Insulin & Sulfonylureas
Your provider may adjust doses to reduce the risk of low blood sugar.
- Monitor blood sugar as directed
- Your provider may adjust doses
- Know the signs of low blood sugar
Oral Medications
Mounjaro may slow the absorption of some oral medications.
- Inform your doctor of all medications
- Take time-sensitive medications as directed
- Discuss contraceptive options if relevant to you
When to Contact Your Healthcare Provider
Most people do not experience serious side effects, but contact a provider if you notice any of the following.
Seek Immediate Care
- Severe or persistent abdominal pain
- Difficulty breathing or swallowing
- Swelling of face, lips, tongue, or throat
- Hives or widespread rash
Contact Your Doctor
- Persistent nausea or vomiting
- Vision changes
- Unusual fatigue or weakness that persists
- Any symptoms that worry you or do not improve